The oral administration of Lop and Cyc reduced visceral fat accumulation and improved hyperglycemia and hyperlipidemia in animal models of diabetes and obesity. 12 Structurally, Aloe sterols fall into two groups of compounds, the Lop group and the Cyc group. Fibroblasts play an important role in generating collagen, HA, and elastin in the dermis.Īloe sterols (lophenol, 24-methyl-lophenol, 24-ethyl-lophenol, cycloartanol, and 24-methylene-cycloartanol) are plant sterols derived from A. HA is responsible for moisture retention in the skin. Collagen forms the three-dimensional structure, and elastin maintains the elasticity of the skin. 10, 11 The dermis tissues also contain collagen, elastin, and hyaluronic acid (HA) as other ingredients. Their major function is to maintain extracellular matrix (ECM) homeostasis. vera on dermal tissues have not been investigated.įibroblasts represent the main cellular population of the dermis. 9 However, the effects of other ingredients in A. 7, 8 A previous report suggested that acemannan stimulated the synthesis of keratinocyte growth factor-1 and vascular endothelial growth factor by gingival fibroblasts in vitro. vera gel and is known to induce immunological responsiveness. 5, 6 Acemannan is the major polysaccharide in A. vera gel contains polysaccharides, amino acids, lipids, plant sterols, tannins, and enzymes. vera for the prophylaxis of radiation-induced dermatitis. 3 A clinical trial demonstrated the usefulness of A. 2 The skin was raised and the recovery period was shortened by applying A. vera gel is obtained from the mesophyll and has been used as a herbal medicine. Aloe vera ( Aloe barbadensis Miller) is a plant species belonging to the family Liliaceae.
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